ISH stands for "in situ hybridization. Food and Drug Administration in June HER2-positive breast cancers make too much of the HER2 protein, which receives signals telling the breast cancer to grow. About one out of every four breast cancers is HER2-positive. Figuring out the HER2 status of a breast cancer is an important step in deciding on a treatment plan.
Topic: ONCOTYPE TEST and FISH TEST
Bladder Cancer | NeoGenomics Laboratories
These HER2 receptors receive signals that stimulate the growth of breast cancer cells. However, FISH is considered more accurate. Research has shown that some HER2 test results may be wrong. This is probably because different labs have different rules for classifying positive and negative HER2 status. Each pathologist also may use slightly different criteria to decide whether the results are positive or negative. In most cases, this happens when the test results are borderline -- meaning they aren't strongly HER2-positive or HER2-negative. In other cases, tissue from one area of a breast cancer can test HER2-positive and tissue from a different area of the cancer can test HER2-negative.
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ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor.